| 名稱(chēng) | Recombinant Human β-NGF |
| 型號 | |
| 更新時(shí)間 | 2023-09-24 |
| 特點(diǎn) | β-NGF神經(jīng)營(yíng)養因子結構與BDNF,NT-3 NT-4相同。β-NGF強有力的神經(jīng)營(yíng)養因子,通過(guò)其受體β-NGFR信號,并在開(kāi)發(fā)和保護中扮演著(zhù)關(guān)鍵角色的感覺(jué)和交感神經(jīng)系統。β-NGF還可以作為B淋巴細胞的生長(cháng)和分化因素型和增強B細胞生存。使用所有無(wú)動(dòng)物生產(chǎn)試劑。} |
產(chǎn)品展示 / PRODUCTS
- 詳細內容
一.產(chǎn)品名稱(chēng)：Recombinant Human β-NGF/重組蛋白β-NGF
二.Catalog Number:AF-450-01
三.Synonyms:NGF-β
四.Description:
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (238 total amino acid residues). The three disulfide bonds are required for biological activity. Manufactured using all non-animal reagents.
五.AA Sequence:
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR
六.Source:E.coli
七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
八.Biological Activity:
Assay 1:Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Assay 2:Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
九.Cross Reactivity:Chicken, Hamster, Mouse, Rat, Human
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電話(huà)/傳真：13366128764
手機：15311648455
地址：北京市海淀區廂黃旗2號樓1層4-179室