| 名稱(chēng) | Recombinant Human TNF-α |
| 型號 | |
| 更新時(shí)間 | 2023-09-24 |
| 特點(diǎn) | TNF-α是pleiotrophic促炎細胞因子分泌的多種細胞包括脂肪細胞,激活單核細胞、巨噬細胞、B細胞、T細胞和成纖維細胞。它屬于TNF家族的配體和信號通過(guò)兩個(gè)受體,TNFR1 TNFR2。TNF-α是各種腫瘤細胞和細胞毒性是一個(gè)重要的中介因素對細菌感染的免疫反應。TNF-α也扮演了重要的角色在感染性休克的感應,自動(dòng)免疫疾病、風(fēng)濕性關(guān)節炎、炎癥和糖尿病。} |
產(chǎn)品展示 / PRODUCTS
- 詳細內容
一.產(chǎn)品名稱(chēng)：Recombinant Human TNF-α/Peprotech TNF-α
二.Catalog Number:AF-300-01A
三.Synonyms:
Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin
四.Description:
TNF-α is a pleiotrophic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein. Manufactured using all non-animal reagents.
五.AA Sequence:
VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL
六.Source:E.coli
七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
八.Biological Activity:
The ED50as determined by the cytolysis of murine L929 cells in the presence of Actinomyocin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
九.Cross Reactivity:Cow, Monkey, Mouse, Rat, Sheep, Human, Dog, Pig, N/A, Human + Virus
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電話(huà)/傳真：13366128764
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電話(huà)/傳真：13366128764
手機：15311648455
地址：北京市海淀區廂黃旗2號樓1層4-179室