一.產(chǎn)品名稱(chēng)：

通用名稱(chēng)：大鼠甲狀旁腺激素C端肽ELISA試劑盒

英文名稱(chēng)：Rat PTH C-Terminal ELISA Kit

二.產(chǎn)品介紹：

Rat intact parathyroid hormone (PTH) is an 84 amino acid polypeptide produced by the parathyroid gland with its biological activity residing in the N-Terminal region of the peptide. PTH plays an important role in
maintaining the concentration of ionized calcium within the limits needed to achieve normal metabolic functions. When serum calcium levels are decreased the parathyroid gland increases secretion from
skeletal reserves into the circulation. When levels of serum calcium are increased the secretion of PTH is reduced.
 

PTH undergoes extensive in-vivo catabolism producing numerous midregion and C-terminal fragments. These fragments have a much longer half-life in circulation than intact PTH and accumulate to high levels.
Since PTH fragments are cleared from circulation by the kidney highly elevated levels can be seen with renal insufficiency. The similarities between rat and human physiology relative to calcium metabolism make the rat an excellent live-animal model for studying skeletal disease and in the pre-clinical evaluation of pharmacologicagents that may alter bone remodeling. The determination of rat PTH with this kit can provide a precise and sensitive assessment of changes in bone and mineral metabolism.

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